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A daily dose of Viagra may reduce the risk of colon cancer

The functioning mechanism of Viagra  -sildenafil or blue pill- is based on relaxing the muscle around the blood vessels so they can fill with blood more easily and facilitate erection . In this way, it helps not only patients with erectile dysfunction , which is its best-known use, but also patients suffering from diseases such as pulmonary arterial hypertension (PPH). But in addition, it could have more functions, according to a study recently published in Cancer Prevention Research , whose authors claim that a small daily dose of Viagra significantly reduces the risk of colorectal cancer or colon cancer., the third cause of death by cancer in the world, only behind the lung and the liver.

The research has been carried out with a model of genetically modified mice to acquire this disease. According to the scientists responsible for the research, belonging to the Department of Biochemistry and Molecular Biology of the Medical College of Georgia at the University of Augusta (United States), Viagra decreases by about 50 percent the formation of polyps , a group of cells from Abnormal growth and often asymptomatic in the lining of the intestines that can become cancerous.

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The new study also suggests that for some miraculous drug increases the levels of the cyclic chemical cyclic guanosine monophosphate GMP , which participates as a second messenger in the routes of transmission of cellular signals. It is known that GMP affects the intestinal lining or epithelium, suppressing in part the excess of cell proliferation , which produces an increase in normal cell differentiation. It also stimulates the natural elimination of abnormal cells, through a process called apoptosis .

The genetically modified mice in the experiment had reduced levels of guanylyl cyclase C (GCC) activating peptides, the main source of GMP. This indicator is also present in human colon cancers. However, the existing polyps were not affected, so, according to the researchers, the drug could be used as a preventive treatment in high-risk patients. In fact, for these scientists, the first clinical trials with viagra in humans should be carried out with patients considered high risk of colorectal cancer, particularly those who have a family history of risk, who have suffered multiple previous polyps and intestinal inflammation chronic or colitis. The most common diagnostic test to detect this type of cancer is colonoscopy.

Is it true that watermelon has effects similar to Viagra?

slice of watermelon could have effects similar to those of Viagra , the drug for erectile dysfunction, and could even increase libido, as recently demonstrated by scientists at the University of Texas (USA). This is due to its content in citrulline , a substance capable of relaxing blood vessels. According to the researchers, when watermelon is consumed, citrulline is converted into arginine, an amino acid that, among other things, “improves the production of nitric oxide which in turn relaxes blood vessels , and this is the same effect as Viagra to treat erectile dysfunction and perhaps prevent it. ”

The only problem is that citrulline is found ingreater concentration in the watermelon rind . Scientists are now investigating the possibility of producing new varieties of fruit with higher concentrations of citrulline in the pulp.





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